研究方向：

1．疱疹病毒1型（BoHV-1）潜伏感染和裂解性感染的分子机理和溶瘤分子机制；2. BoHV-1病毒诱导炎症反应发生的分子机理； 3. BoHV-1和牛病毒性腹泻病毒（BVDV）检测技术及疫苗。

主持的课题：

1. BoHV-1感染抑制53BP1依赖的对DNA损伤进行修复的分子机理研究, 国家

自然科学基金面上项目(No. 31972655), 2020/01- 2023/12，59万元（主持）

2. β-Catenin信号调节BoHV-1潜伏感染和裂解性感染的分子机理研究，国家自然科学基金面上项目（No. 31772743），2018/1-2021/12，59万元（主持）

3. PLC/钙离子信号在BoHV-1感染中的作用研究，国家自然科学基金面上项目（No.31472172），2015/01-2018/12，72万元（主持）

4. 科技部十三五国家重点研发专项“猪重要疫病抗原快速检测技术研究”子课题（No.2016YFD0500704）(牛病毒性腹泻病毒抗原诊断)，2016-2020，30万元（主持）

5. HMGA1调节BoHV-1病毒感染的分子机制研究，农业部动物免疫学重点实验室/河南省动物免疫学重点实验室开放课题 (No. KLAI20170602）, 2017/06 -2019/06, 10万元（主持）

6. BoHV-1潜伏感染模型的建立及β-catenin调节该病毒感染的分子机制 （C02220106），2022年河北省自然科学基金春晖人才计划： 2022/01/01-2024/01/01，10万元（主持）。

7. A549细胞产生的BoHV-1感染力下降的分子机制及其用于培育弱毒疫苗株的探索研究（C20220501），2022年河北省引进留学人员启动经费（优秀类），2022/09-2025/09，5万元（主持）

8. BoHV-1 gD 蛋白介导的溶瘤效应机制研究，2022年河北省自然科学基金（生物医药联合基金）(H2022201081)，2022/01/01-2024/01/01，10万元（参与）。

以第一作者或通信作者发表SCI论文40余篇，部分论文如下：

1. Xiuyan Ding, Shitao Li, Liqian Zhu*, Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: a promising therapeutic target for virus infection-induced inflammatory diseases. Cytokine & Growth Factor Reviews. 2021, 62:54-61.

2. Ding X, Neumann DM*, Zhu L*. Host factors associated with either VP16 or VP16-induced complex differentially affect HSV-1 lytic infection. Rev Med Virol. 2022, 7: e2394.

3. Xinye Chen(#), Xiuyan Ding(#), Liqian Zhu*, GaipingZhang*. The identification of a B-cell epitope in bovine viral diarrhea virus (BVDV) core protein based on a mimotope obtained from a phage-displayed peptide library. Int J Biol Macromol. 2021, 183: 2376-2386

4. Wenqing Fan, Weifeng Yuan, Xiuyan Ding, Liqian Zhu*. β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture. Virulence. 2021, 12(1):1345-1361

5. Xiaotian Fu (#), Dongmei Chen (#), Yan Ma, Weifeng Yuan, and Liqian Zhu*. Bovine Herpesvirus 1 Productive Infection Led to Inactivation of Nrf2 Signaling through Diverse Approaches. Oxidative Medicine and Cellular Longevity. 2019, 4957878.

6. Aspen Workman(#), Liqian Zhu(#), Brittany Keel, Timothy Smith, and Clinton Jones*. The Wnt signaling pathway is differentially expressed during the bovine herpesvirus 1 latency-reactivation cycle: evidence that two protein kinases associated with neuronal survival (Akt3 and bone morphogenetic protein receptor 2) are expressed at higher levels during latency. J Virol. 2018, 14;92(7). (co-first author)

7. Zhu L, Workman A, Jones C. A potential role for a β-catenin coactivator (high mobility group AT-hook 1 protein) during the latency-reactivation cycle of bovine herpesvirus 1. J Virol. 2017 Feb 14;91(5)

8. Zhu L, Thunuguntla P, Liu Y, Hancock M, Jones C. The β-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection. Virology. 2017. 500:91-95.

9. Liqian Zhu, Jessie Thompson, Fangrui Ma, James Eudy, Clinton Jones. Effects of the synthetic corticosteroid dexamethasone on bovine herpesvirus 1 productive infection. Virology. 2017. 505:71-79.

10. Liqian Zhu^(#), Chen Yuan^(#), Xiuyan Ding, Shuai Xu, Yuying Liang *, Qiyun Zhu*, PLC- gamma1 is involved in the inflammatory response induced by influenza A virus H1N1 infection, Virology, 2016, 496:131–137.

11. Liqian Zhu, Yuying Liang*, Hinh Ly, PLCgamma1 signaling plays a subtype-specific role in post-binding cell entry of Influenza A virus. J Virol. 2014, 88(1):417-24.

授权专利：

牛病毒性腹泻病毒抗体检测试纸及其制备方法.发明专利, 2018, 专利申请号:201810604281.X，（联合申请，第二申请人）已授权。