姓名：忙定泽

职称：教授/研究员，博士生导师

邮箱：mangdz@163.com;mang@hbu.edu.cn

联系地址：河北省保定市五四东路180号，河北大学逸夫楼706室，

邮编：071002

Webpage in English：https://researchmap.jp/40896809?lang=en

【个人简介】

忙定泽，男，1988年11月生，贵州册亨人，博士，教授/研究员，博士生导师，河北省青年科学基金（A类）获得者、省青年拔尖人才及省特聘专家，中国昆虫学会第十一届昆虫生理生化与分子生物学专委会青年委员。

主要从事生物化学与分子生物学研究，重点聚焦昆虫化学感受及营养代谢调控机制。作为项目/课题负责人，先后主持国家重点研发计划项目青年科学家课题、日本学术振兴会科学基金、河北省青年科学基金（A类）及省高层次人才（青年拔尖）资助项目等。已发表学术论文40余篇，其中以第一或通讯作者（含共同）在Insect Biochemistry and Molecular Biology、Entomologia Generalis、Pest Management Science、Journal of Agricultural and Food Chemistry、ACS Applied Materials & Interfaces、Chemical Communications等国际知名期刊发表论文20余篇。

已培养毕业硕士生2名、本科生4名；在读博士生3名，硕士生12名、在站博士后1名。

招生方向：

博士研究生（生物学/生态学）

硕士研究生（生物化学与分子生物学/生物与医药）

教育经历：

2013.03–2016.03 博士，东京农工大学

2012.04–2013.03日本语学习，富士国际语学院早稻田校

2009.09–2012.07硕士，贵州师范大学

2010.07–2012.04联合培养硕士，中国科学院动物研究所

2005.09–2009.07 学士，贵州师范大学

工作经历：

2023.11至今 教授/研究员，博士生导师，河北大学

2023.06–2023.11 研究员（校聘），博士生导师，河北大学

2022.04–2023.06 研究员（校聘），硕士生导师，河北大学

2020.04–2022.03Assistant Professor，东京农工大学

2016.06–2020.04博士后，日本冲绳科学技术大学院大学

奖励荣誉：

2025.07获河北省青年科学基金A类（原省杰青项目）资助

2024.05入选河北省青年拔尖人才、被聘为省级特聘专家

2023.02入选中国昆虫学会第十一届昆虫生理生化与分子生物学专委会青年委员

2018.12获国际多肽研讨会“优秀发表奖”(日本京都)

2016.03东京农工大学优秀博士毕业生

2015.07东京农工大学同窗会研究课外活动奖

2015.04第四届国际(亚太)蚕业与昆虫生物技术大会获“杰出青年学者奖”(韩国釜山)

2015.04–2016.03国际Rotary米山纪念财团奖学金

2014.04–2015.03东京农工大学(JIRITSU)研究奖励金

2013.04–2014.03东京农工大学(JIRITSU)研究奖励金

2011.12被评为“贵州师范大学2011–2012年度优秀研究生”

2010.10获全国第三届大学生节能减排社会实践与科技竞赛“科信能环杯”三等奖

2010.07获贵州省首届“硕博论坛”二等奖

杂志审稿人:

担任Entomologia Generalis、Insect Biochemistry and Molecular Biology、Journal of Agricultural and Food Chemistry、iScience、Pest Management Science、Pesticide Biochemistry and Physiology、Insect Molecular Biology等10余种SCI期刊的独立审稿人。

小组成员：

学生获奖：

2024.11张文静，获2024年研究生国家奖学金；

2024.11张文静、李建俏、崔哲博、高紫怡、王露获2024年一等学业奖学金；

2024.12崔哲博获石药奖学金；

2023.11崔哲博，获第六届全国入侵生物学大会“优秀墙报奖”，（中国，重庆）；

2023.10孙静，获2023年研究生国家奖学金；

2023.10孙静，获2023年一等学业奖学金；

2023.08孙静，获2023年国际昆虫学大会ICIS“优秀墙报奖”，（中国，河北）；

【科研领域】昆虫生态与分子生物学

本课题组主要聚焦于昆虫化学感受与营养代谢的分子调控机制，以家蚕、美国白蛾、红火蚁等重要经济昆虫和入侵害虫为研究对象，综合运用生理学、生物化学、细胞生物学、分子生物学、遗传学及多组学等交叉学科方法，在细胞、器官与个体等多个层次系统解析昆虫化学感受、内分泌调控及代谢互作等关键科学问题。研究重点关注“口器–脑–肠道”调控轴，围绕以下五个核心方向展开：1）昆虫化学感受受体（如味觉与嗅觉受体）在识别寄主植物化学信号中的功能与分子机制；2）食物摄入后营养物质的持续感知机制及营养状态对味觉系统的反馈调节；3）味觉与嗅觉系统在行为调控中的分子作用机理；4）味觉系统与消化系统之间的内分泌互作与调控网络；5）肠道来源的饥饿/饱腹信号因子的释放机制及其生理功能。通过系统性的多维研究，本课题组旨在揭示昆虫化学感受与营养代谢协同调控的分子与生理基础，为害虫防控和益虫利用提供新思路与靶标。

【科研项目】

1.2022/11-2025/10，国家重点研发计划“重大/新发入侵种大规模群体维持和灾变机理”项目青年科学家课题，338万元，在研，课题负责人；

2.2025/01-2027/12，河北省自然科学基金青年科学基金（A类）项目“美国白蛾多寄主选择机理与靶向行为调控策略”，50万元，在研，项目负责人；

3.2024/05-2027/04，河北省高层次人才（青年拔尖）资助项目“外来入侵害虫大规模群体形成与维持规律研究”，50万元，在研，项目负责人；

4.2025/01-2025/12，河北大学生命科学与绿色发展研究院青年拔尖人才项目，美国白蛾味觉识别及营养代谢机，制20万元，在研，项目负责人；

5.2022/01-2023/12，河北大学生命科学与绿色发展研究院重点项目，外来入侵种美国白蛾糖受体对幼虫取食选择的调控机制，180万元，已结题，项目负责人；

6.2021/04-2024/03，日本学术振兴会科学研究经费，Deciphering thefunctions ofgustatory receptors in the recognition of host plant and midgut environment using knockout silkworms，30万元，已结题，项目负责人；

7.2020/04-2022/05，东京农工大学与美国CotevaAgriscience校企合作项目，Collaborativeresearchproject on phage display technology，220万元，已结题，日方项目负责人。

【代表性论文】

（^†共同第一作者, *通讯作者）

2025年

1.Zhang W., Liu H., Sun J.,Mang D.,*2025.Molecularbasis ofquinine-inducedfeedingsuppression inHyphantria cunealarvae.Pest Management Science.(Minor revision) (JCR一区，IF = 4.1)

2.Cui Z.,^†Zhang W.,^†Gao Z.,^†Endang R., Li Yan, Sun J.,Mang D.,*2025. Glucose-induce activation of CCHamide2 via gustatory receptor to regulate metabolism in an invasive pest.Entomologia Generalis,(Minor revision) (JCR一区，IF = 5.6)

3.LiuB.,^†Zhang W.,^†Li J., Sun J.,Mang D.,*2025.Olfactory-mediatedchemotaxistoward akeyhostplantleafvolatile inthe fall webworm.Pest Management Science.(Accepted) (JCR一区，IF = 4.1)

4.Cui Z.,^†Gao Z.,^†Li Y., Sun J., Mang D.,*2025.Heat-sensing receptor pathway promotes thermal tolerance via chitin remodeling in an invasive lepidopteran pest.Entomologia Generalis.DOI: 10.1127/entomologia/3386(JCR一区，IF = 5.6)

5.Mang D.,*2025. Physiological Roles of Chemosensory Receptors in Lepidoptera. Chapter in “Advances in Entomology”.DOI: 10.5772/intechopen.1010863

2024年

1.Sun J..^†Zhang WJ.,^†, Cui Z., Pan Y.., Guy S., Zhang L., Wickham J., Sun J.,*Mang D.,*2024.HcGr76 responds to fructose and chlorogenic acid and involves in regulation of peptides expression in the midgut ofHyphantria cunealarvae.Pest Management Science.80 (11): 5672-5683. (JCR一区，IF=4.10)

2.Zhou Z.,^†Mang D.,^†Smagghe G., Liu Y., Mu Y., Yang L., Wang X., Chen X.,*2024. A Farnesyl Pyrophosphate Synthase Gene Is Expressed in Fat Body Regulates Cantharidin Synthesis in Male Epicauta impressicornis Blister Beetle.Journal of Agricultural and Food Chemistry,72 (23): 12935-12945.(JCR一区，IF=5.895)

3.YuanT.,^†Mang D.,^†Purb, E.R.,^†Ye J., Qian J., Rao F., Wang H., Wu Z., Zhang W., Zheng Y., Zhang Q., Li Z.,*Zhang L.,*2024. Identification and Functional Analysis of Odorant Binding Proteins inApriona germari(Hope).Journal of Agricultural and Food Chemistry.72 (31): 17248-17259. (JCR一区，IF=5.895)

4.Li, J., Chen, Y., Wang, Q., Yin, M., Ma, S., Liu, Q., Sun, X., Zhang, W., Yang, Y.,Mang, D.,Zhu, X., Sun, L., Zhang, Y., 2024. Gustatory Receptor 206 Participates in the Foraging Behavior of Larvae of Polyphagous PestSpodoptera litura.Journal of Agricultural and Food Chemistry,72 (21): 12003–12013.(JCR一区，IF=5.895)

5.Endo, H., Tsuneto, K.,Mang, D.,Wenjing Zhang,Yamagishi, T., Ito, K., Nagata, S., Sato, R., 2024. Two gustatory receptors involved in host plant recognition of silkworm larvae.Journal of Insect Physiology.154: 104628 (JCR二区，IF=2.3)

2023年

1.Mang D.,*Toyama, T., Yamagishi, T., Sun J., R. Purba E., Endo H., M. Matthews M., Ito K.,Nagata N., Sato, R.,*2023.Dietary compounds activate an insect gustatory receptor on enteroendocrine cells to elicit myosuppressin secretion.Insect Biochemistry and Molecular Biology.155, 103927. (JCR一区，IF=4.421).

2.Zhang,X.,^†R. Purba,E.,^†Sun,J.,^†Zhang,Q., Dong,S., Zhang,Y., He,P.,Mang,D.,*ZhangL.,*2023. Functional differentiation of two general-odorant binding proteins inHyphantria cunea(Drury).Pest Management Science. 79 (9): 3312-3325.(JCR一区，IF=4.10)

3.刘丹,邓竣丹,许维康,顾天滋,忙定泽*,张龙娃*.美国白蛾触角感器的扫描电镜观察[J].植物保护学报.2023,50(2):507-518.（中国科技核心期刊）

2022年

1.Mang D.,^†*Mayu K^†, Toyama, T., Yamagishi, T.,Sato, R.,*2022.BmGr4 responds to sucrose and glucose and expresses in tachykinin-related peptide-secreting enteroendocrine cells.Insect Biochemistry and Molecular Biology. 150,103858.(JCR一区，IF=4.421).

2.Liu,D., Deng, J., Xu, W., Gu, T., Rinawati, P.E., Zhang,Q-H., Wickham, J.D.,Mang, D.,*Zhang, L.,* 2022. Ultrastructureof Sensilla on the Antennae and Mouthparts ofHyphantria cuneaLarvae.PeerJ.(JCR二区，IF=2.984).

3.Wu, Z., Ye, J., Qian, J.,Purba, E.R.,Zhang, Q., Zhang, L.*,Mang, D.,*2022. Identification and Expression Profile of Chemosensory Receptor Genes inAromia bungii(Faldermann) Antennal Transcriptome.Insects.13, 96. https://doi.org/10.3390/insects13010096(JCR二区，IF=3.139).

2021年

1.Ye, J.,^†Mang, D.,^†Ke, K., Cheng, C., Zhang, X., Tang, Y., Song. L., Zhang, Q., Zhang, L., 2021. Putative Carboxylesterase Gene Identification and Their Expression Patterns inHyphantria cunea(Drury).PeerJ.e10919.(JCR二区，IF=2.984)

2.Wang, Y., Adegawa,S.,Miyamoto, K., Takasu, Y., Iizuka, T., Wada, S.,Mang, D.,S., Li, X., Kim, S., Sato, R., Watanabe, K., 2021.ATP-binding cassette transporter subfamily C members 2, 3 and cadherin protein are susceptibility-determining factors inBombyx morifor multipleBacillus thuringiensisCry1 toxins.Insect Biochemistry and Molecular Biology. 139: 103649(JCR一区，IF=4.421)

3.Shii, F.,Mang, D.,Dingze Mang, Kasubuchi, M., Tsuneto, K., Toyam, T., Sasaki,K., Endo, H.,Sato, R., 2021. Ultrasensitive detection by maxillary palp neurons allows non-host recognition without consumption of harmful allelochemicals.Journal of Insect Physiology.132: 104263.(JCR一区，IF=2.608)

4.Li G.,Hu, X., Nie, P.,Mang, D.,Jiao, S, Zhang, S., Zhou, Y., Hoh, H., Roy, S., Yukawa, S., Asahina, S., Sugasawa, H., Cortes, W., Zhou, Z., Zhang, Y., 2021. Lipid-raft-targeted Molecular Self-assembly Inactivates YAP to Treat Ovarian Cancer.NanoLetetrs.21, 747−755.(JCR一区，IF=12.262)

5.Mang, D.,^†Roy SR.,^†Zhang Q.,^†Hu, X.,Zhang, Y., 2021.Heparan-Sulfate-Instructed Self-Assembly Selectively Inhibits Cancer Cell Migration.ACS Applied Materials & Interfaces.13, 15, 17236–17242.(JCR一区，IF=10.383)

2020年

1.Mang, D.,^†Sona R.,^†Hong H. H., Wu, X.,Zhang,J.,Jin, C., Zhang, Y., 2020.Self-assembly of Integrin Ligands on Apical Membrane Inhibits the Migration of Glioma Cell.Langmuir. 36(14):3750–3757.(JCR二区，IF=4.331)

2.Zhu, X., Xu, J., Li, L., Wang, D., Zhang, M., Yu, N., Purba, E. R., Zhang, F., Li, X., Zhang, Y*.,Mang, D.,*2020.Analysis of Chemosensory Genes inSemiothisa cinereariaReveals Sex-Specific Contributions for Type-II Sex Pheromones Chemosensation.Genomics.112 (6): 3846-3855.(JCR二区，IF=4.301)

3.Zhang,X.,^†Mang, D.,^†Liao, H., Ye, J., Qian, J., Dong, S., Zhang, Y., He, P., R. Purba, E., Zhang, L., 2020. Functional disparity of three pheromone-binding proteins to different sex pheromone components inHyphantria cunea(Drury).Journal of Agricultural and Food Chemistry.69, 55−66.(JCR一区，IF=5.895)

4.Qian, J.,^†Mang, D.,^†Lv, G., Ye, J., L, Z., Chu, B., Sun, L., Liu, Y., Zhang, L., 2020..Identification and Expression Profile of Olfactory Receptor Gene Based onApriona germari(Hope) Antennal Transcriptome.Frontiers in Physiology.doi: 10.3389/fphys.2020.00807(JCR二区，IF=4.755)

5.He, P.,^†Mang, D.,^†Wang,H.,Wang, M., Ma, Y., Chen, G., Wang, J., Zhang, F., He. M., 2020. Molecular characterization and functional analysis of aSpodoptera exiguaubiquitous carboxylesterase suggested it acted as a cuticle enzyme degradation of ester chemical stimulus.Pesticide Biochemistry and Physiology.163, 227–234.(JCR二区，IF=4.966)

6.Zhang,Y., Zhang, X., Zhang, X., Xu, J., Li,L., Zhu, X., Wang, J., Wei, J.,Mang, D.,Zhang,F., Yuan,X., Wu, X., 2020. Key amino acid residues influencing binding affinities of pheromone binding protein fromAthetis lepigoneto two sex pheromones.Journal of Agricultural and Food Chemistry. 6092–6103.(JCR一区，IF=5.895)

7.Zhang, Y., Xu, J., Zhang, X., Zhang, X., Li, L., X., Yuan,Mang, D.,Zhu, X., Zhang, F., Dewer, Y., Xu, L., Wu, X., 2020. Organophosphorus insecticide interacts with the pheromone-binding proteins ofAthetis lepigone: implication for olfactory dysfunction.Journal of Hazardous Materials.397, 122777.(JCR一区，IF=14.224)

8.Zhang,X., Yan, Q., Li, L., Xu, J.,Mang, D.,Wang, X., Hoh, H., Ye, J., Ju, Q., Ma, Y., Liang M., Zhang, Y., Zhu, X., Zhang, F., Dong, S., Zhang, Y., Zhang, L., 2020. Different binding properties of two general-odorant binding proteins inAthetis lepigonewithsex pheromones, host plant volatiles and insecticides.Pesticide Biochemistry and Physiology.164, 173–182.(JCR二区，IF=4.966)

2019年

1.Mang, D.,^†Zhang, S.,^†Wu, X., Mochizuki T., Li G., Zhang, Y., 2019. Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect.Chemical Communications. 55, 6126–6129.(JCR一区，IF=6.065).

2.Zhang, S., Hu, X.,Mang, D.,Sasaki, T., Zhang, Y., 2019. Self-delivery of N-hydroxylethyl Peptide Assemblies to the Cytosol Inducing Cancer Cell Endoplasmic Reticulum Dilation.Chemical Communications. 55, 6126–6129.(JCR一区，IF=6.065)

2018年

1.Du, E., Hu, X., Li, G., Zhang, S.,Mang, D.,Roy, S., Sasaki, T., Zhang, Y., 2018. Self-assembly-Directed Cancer Cell Membrane Insertion of Synthetic Ananlogues for Permeability Alteration.Langmuir, 35 (23), 7376-7382.(JCR二区，IF=4.331)

2016年

1.Mang, D.,^†Shu, M.,^†Tanaka, S., Nagata, S., Takada, T., Endo, H., Kikuta, S., Tabunoki, H., Iwabuchi, K., Sato, R., 2016.Expression of the fructose receptor BmGr9 and its involvement in the promotion of feeding, suggested by its co-expression with neuropeptide F1.Insect Biochemistry and Molecular Biology. 75, 58–69.(JCR一区，IF=4.421).

2.Mang, D.,Shu, M., Endo, H., Yoshizawa, Y., Nagata, S., Kikuta, S., Sato, R., 2016. Expression of a sugar clade gustatory receptor, BmGr6, in the oral sensory organs, midgut, and central nervous system of larvae of the silkwormBombyx mori.Insect Biochemistry and Molecular Biology.70, 85–98.(JCR一区，IF=4.421)

3.Shu, M.,Mang, D.,Sunfu, G., Tanaka, S., Endo, H., Kikuta, S.,Sato, R., 2016. Mechanisms of nodule-specific melanization in the hemocoel of the silkworm,Bombyx mori.Insect Biochemistry and Molecular Biology, 70, 10–23.(JCR一区，IF=4.421)

2016年之前

1.忙定泽，罗庆怀,舒敏,韦卫.长足大竹象成虫体表信息化学物质的提取和鉴定[J].昆虫学报.2012,55 (3): 133-138.（中国科技核心期刊）

2.忙定泽,罗庆怀,舒敏,孙翠英.中国豆野螟发生与防治研究沿革、进展及展望[J].中国农学通报.2012,28(4): 79-88.（中国科技核心期刊）

3.龙见坤,罗庆怀,忙定泽,石庆型,潘盛波.小型寄生蜂采集方法的简便有效改进及贵州稻田寄生蜂新记录[J].中国生物防治学报. 2010(S1).（中国科技核心期刊）

4.潘盛波,罗庆怀,龙见坤,张志燕,忙定泽,舒敏.贵州发现黄杨绢野螟黑化个体及正常个体翅斑的变化[J].应用昆虫学报,2011,48(1):212-213.（中国科技核心期刊）

5.龙见坤,罗庆怀,潘胜波,忙定泽,舒敏,张志燕.贵阳市金叶女贞上访花食蚜蝇物种多样性及其访花行为研究[J].环境昆虫学报,2010,32(2):235-242.（中国科技核心期刊）

6.舒敏,张志燕,罗庆怀,王祖泽,忙定泽,朱小青,阎崇斌,贵州首次发现蔬菜检疫性害虫菜黑斯象及初步调查[J].长江蔬菜,2010,(11):45-46.

学术会议发表

1.Mang, D.,Zhang, Y. Self-assembly of Integrin Ligands on Apical Membrane Inhibits the Migration of Glioma Cell. The100th Annual Meeting of CSJ. Chiba, Japan, March 21–25, 2020. (Poster)

2.Mang, D.,Sona R., Hong H. H., Wu, X., Li G., Hu, X., Zhang, Y. Laminin-derived peptide FFFYIGSR self-assembled to inhibit glioma cell migrationand invasion.The 42nd Annual Meeting of the Molecular Biology Society of Japan (MBSJ). Fukuoka, Japan, December 3–6, 2019. (Poster).

3.Mang, D.,Zhang, S., Wu, X., Mochizuki, T., Zhang, Y., Enzyme-mediated dual-targeted-assembly achieves synergetic anticancer effect. The 8th International Conference on Nanoscience and Technology. Beijing, China, August 16–19, 2019.(Poster)

4.Mang, D.,Wu, X., Zhang, Y. Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect. The 98th Annual Meeting 2019 of CSJ. Kobe, Japan, March 16–19, 2018. (Oral)

5.Mang, D.,Zhang, S., Wu, X., Zheng, Y., Zhang, Y. Enzyme-sorted-assembly of chiral peptides kills cancer cell via multi-subcellular targeting. 10th International Peptide Symposium Registration Confirmation. Kyoto, Japan, December 3–7, 2018. (Poster)

6.Mang, D.,Morita, C., Shimomura, K., Tomita, N., Kikuta, S., Sato, R. Distribution of a gustatory receptor expressing cells in the midgut ofthe silkworm,Bombyx morilarvae.The 4th Asia-Pacific Congress of Sericulture and Insect Biotechnology. Abstract: 84,Busan, Korea, April 23–25, 2015. (Oral)