个人简介

张宏冰教授，男，1962年3月出生，湖北人，先后毕业于三峡大学医学院、华中科技大学同济医学院、美国宾夕法尼亚大学（University of Pennsylvania）医学院，为哈佛大学医学院博士后/讲师、中国医学科学院-北京协和医学院长聘教授、中华医学基金会杰出教授、国家杰出青年科学基金获得者、2014-2023中国高被引学者（Highly Cited Chinese Researchers）、全球前2%顶尖科学家。主要从事肿瘤信号传导通路异常与靶向治疗的教学和科研工作。在Cell、Nature、Lancet、PNAS、JCI、Gastroenterology、Gut、Am J Gastroenterol、Am J Respir Crit Care Med、Thorax、Cell Death Differ、Autophagy、Cancer Res、Oncogene、Hum Mol Genet、JBC等学术刊物发表过论文。

近10年发表的论文：

1. Huang F, Guo J, Zhao N, Hou M, Gai X, Yang S, Cai P, Wang Y, Ma Q, Zhao Q, Li L, Yang H, Jing Y, Jin D, Hu Z, Zha X, Wang H, Mao Y, Liu F,Zhang H. PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.J Transl Med. 2024 Mar 8;22(1):254.

2. Wang Y, Hu D, Wan L, Yang S, Liu S, Wang Z, Li J, Li J, Zheng Z, Cheng C, Wang Y, Wang H, Tian X, Chen W, Li S, Zhang J, Zha X, Chen J,Zhang H, Xu KF. GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1.Am J Respir Cell Mol Biol. 2024 Mar;70(3):178-192.

3. Liu F, Wu Y, Zhang B, Yang S, Shang K, Li J, Zhang P, Deng W, Chen L, Zheng L, Gai X,Zhang H. Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis.Chin Med J(Engl). 2024 Jan 20;137(2):181-189.

4. Huang F, Zhao N, Cai P, Hou M, Yang S, Zheng B, Ma Q, Jiang J, Gai X, Mao Y, Wang L, Hu Z, Zha X, Liu F,Zhang H. Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer.Transl Res. 2024 Jan 18:S1931-5244(24)00014-8.

5. Chen R, Wang H, Zheng C, Zhang X, Li L, Wang S, Chen H, Duan J, Zhou X, Peng H, Guo J, Zhang A, Li F, Wang W, Zhang Y, Wang J, Wang C, Meng Y, Du X,Zhang H. Polo-like kinase 1 promotes pulmonary hypertension.Respir Res. 2023 Aug 19;24(1):204.

6. Jiang D, Xiao H, Zheng X, Dong R,Zhang H, Dai H. Interleukin-17A plays a key role in pulmonary fibrosis following Propionibacterium acnes-induced sarcoidosis-like inflammation.Exp Biol Med (Maywood). 2023 Jul;248(14):1181-1190.

7. Gai X, Liu F, Wu Y, Zhang B, Tang B, Shang K, Wang L, Zhang H, Chen Y, Yang S, Deng W, Li P, Wang J,Zhang H. Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis.Animal Model Exp Med. 2023 Apr;6(2):92-102.

8. Wu Y, Yang S, Han L, Shang K, Zhang B, Gai X, Deng W, Liu F,Zhang H. β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer.J Transl Med. 2023 Jan 26;21(1):50.

9. Tang B, Wang Y, Xu W, Zhu J, Weng Q, Chen W, Fang S, Yang Y, Qiu R, Chen M, Mao W, Xu M, Zhao Z, Cai S,Zhang H, Ji J. Macrophage xCT deficiency drives immune activation and boosts responses to immune checkpoint blockade in lung cancer.Cancer Lett. 2022 Nov 29;554:216021.

10. Liu F, Gai X, Wu Y, Zhang B, Wu X, Cheng R, Tang B, Shang K, Zhao N, Deng W, Chen J, Zhang Z, Gu S, Zheng L,Zhang H. Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer.Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2202157119.

11. Zhang X, Zheng C, Gao Z, Chen H, Li K, Wang L, Zheng Y, Li C, Zhang H, Gong M,Zhang H, Meng Y. SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis.Cardiovasc Drugs Ther. 2022 Jun;36(3):437-447.

12. Dai Y, Zhang X, Lv J, Feng F, Wan X, Huang F,Zhang H, Zhu L. Familial uterine leiomyoma-associated germline oncogenic mutant VEGFR1 is sensitive to mTOR inhibitor.Sci Bull(Beijing). 2022 Mar 30;67(6):585-587.

13. Zhou X, Sun Z, Zhang M, Qu X, Yang S, Wang L, Jing Y, Li L, Deng W, Liu F, Di J, Chen J, Wu J,Zhang H.Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.Animal Model Exp Med. 2022 Feb;5(1):61-71.

14. Wang L, Wang F, Liu K, Long C, Chen Y, Li C, Li L, Liu F, Zhang X, Jing Y, Wang Y, Liang A, Yan H,Zhang H. αB-crystallin/HSPB2 is critical for hyperactive mTOR-induced cardiomyopathy.J Cell Physiol. 2021 Dec;236(12): 8110-8121.

15. 王莹，张宏冰。第3章（pp47-59）mTOR信号通路调节自噬，自噬生物学与疾病基础卷（第3版），科学出版社，2021.

16. Zhou J, Zhao Z, Sun T, Liu W, Yu Z, Liu J, Yu Y, Ning S,Zhang H. Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study.Am J Gastroenterol. 2021 May 1;116(5):1044-1052.

17. Pu Y, Song Y, Zhang M, Long C, Li J, Wang Y, Xu Y, Pan F, Zhao N, Zhang X, Xu Y, Cui J, Wang H, Li Y, Zhao Y, Jin D,Zhang H.GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis.Signal Transduct Target Ther. 2021 Apr 14;6(1):148.

18. Gao Y, Ma X, Bi J, Chu J, Liu B, Chi C, Yan J, Yu X, Liu F, Deng X,Zhang H, Jin B. Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history.Virulence. 2020 Dec;11(1):1015-1023.

19. Li C, Chen H, Lan Z, He S, Chen R, Wang F, Liu Z, Li K, Cheng L, Liu Y, Sun K, Wan X, Chen X, Peng H, Li L, Zhang Y, Jing Y, Huang M, Wang Y, Wang Y, Jiang J, Zha X, Chen L,Zhang H. mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis.Cell Death Differ. 2019 Oct;26(10):2015-2028.

20. Wang Y,Zhang H. Regulation of Autophagy by mTOR Signaling Pathway.Adv Exp Med Biol. 2019;1206:67-83.

21. Gai X, Tang B, Liu F, Wu Y, Wang F, Jing Y, Huang F, Jin D, Wang L,Zhang H. miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3β/MMPs.J Genet Genomics. 2019 May 20;46(5):235-245.

22. 徐凯峰，金美玲，刘杰，欧阳若芸，田欣伦，张波，张宏冰，中华医学会呼吸病学分会间质性肺疾病学组。西罗莫司治疗淋巴管肌瘤病专家共识(2018)。中华结核和呼吸杂志,2019,42( 2 ): 92-97。

23. 王莹，张宏冰。第三章mTOR信号与自噬调节，自噬生物学与疾病基础卷，科学出版社，2019

24. 王冬梅，孟真，张宏冰。雷帕霉素靶蛋白抑制剂西罗莫司治疗晚期骨髓纤维化，中华医学杂志2018;98(2):154-155。

25. Sun Q, Li S, Wang Y, Peng H, Zhang X, Zheng Y, Li C, Li L, Chen R, Chen X, Bai W, Jiang X, Liu L, Wei F, Wang B, Zhang Y, Li H, Ren X,Zhang H. Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosis.Cell Death Differ. 2018 Jun;25(6):1160-1173.

26. Xu KF, Tian X, Yang Y,Zhang H. Rapamycin for lymphangioleiomyomatosis: optimal timing and optimal dosage.Thorax. 2018 Apr;73(4):308-310.

27. Wu H, Wu Z, Li P, Cong Q, Chen R, Xu W, Biswas S, Liu H, Xia X, Li S, Hu W, Zhang Z, Habib SL, Zhang L, Zou J,Zhang H, Zhang W, Li B. Bone Size and Quality Regulation: Concerted Actions of mTOR in Mesenchymal Stromal Cells and Osteoclasts.Stem Cell Reports. 2017 Jun 6;8(6):1600-1616.

28. Chen R, Duan J, Li L, Ma Q, Sun Q, Ma J, Li C, Zhou X, Chen H, Jing Y, Zhao S, Wu X,Zhang H. mTOR promotes pituitary tumor development through activation of PTTG1.Oncogene. 2017 Feb 16;36(7):979-988.

29. Liu Z, Mao J, Wu X, Xu H, Wang X, Huang B, Zheng J, Nie M,Zhang H. Efficacy and Outcome Predictors of Gonadotropin Treatment for Male Congenital Hypogonadotropic Hypogonadism: A Retrospective Studyof 223 Patients.Medicine (Baltimore). 2016 Mar;95(9):e2867.

30. Wang L,Zhang H, Li C, Yi Y, Liu J, Zhao Y, Tian J, Zhang Y, Wei X, Gao Y, Liang A. Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity.PLoS One. 2016 Oct 7;11(10):e0164215.

31. Chen X, Wang Y, Tao J, Shi Y, Gai X, Huang F, Ma Q, Zhou Z, Chen H,Zhang H, Liu Z, Sun Q, Peng H, Chen R, Jing Y, Yang H, Mao Y, Zhang H. mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice.Gastroenterology. 2015 Sep;149(3):741-52.e14.

32. Hu Z, Wang Y, Huang F, Chen R, Li C, Wang F, Goto J, Kwiatkowski DJ, Wdzieczak-Bakala J, Tu P, Liu J, Zha X,Zhang H. Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.J Biol Chem. 2015 Oct 16;290(42):25756-65.

33. Chen R, Li S, Liu G, Yuan Y, Liu J, Liu T, Wu R, Sun Q, Ren X, Yi X,Zhang H. Digital Karyotyping with Whole Genomic Sequencing for Complex Congenital Disorder.J Genet Genomics. 2015 Nov 20;42(11):651-655.

34. 茅江峰，陈蓉蓉，伍学焱，刘兆祥，郑俊杰，王曦，聂敏，段婧，张宏冰。先天性低促性腺激素性性腺功能减退症男性患者的性腺轴外表现和致病基因间的关系。中华医学杂志2015; 95:3424-7.

35. Zha X, Hu Z, Ji S, Jin F, Jiang K, Li C, Zhao P, Tu Z, Chen X, Di L, Zhou H,Zhang H. NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth.Cancer Lett. 2015 Apr 1;359(1):97-106.