个人简介
张继泉，男，1975年2月生，山东济南人，博士，教授，博士研究生导师，河北大学坤舆优秀学者二层次。兼任中国动物学会比较内分泌学专业委员会委员、河北省动物学会理事等。
主要从事水产动物遗传与育种方面的教学和科研工作。2018年至今，主持国家自然科学基金面上项目（3项）、国家重点研发计划项目子课题、河北省重点研发项目、河北省教育厅重点项目、河北省自然科学基金（2项）等多项课题；以发表第一作者/通讯作者发表SCI期刊源论文40余篇；获授权国家发明专利3件（第一发明人）；获2019年度河北省自然科学三等奖1项（排名第1位）。
已培养硕士12名、本科生30余名；在读博士生4名、硕士生22名。
教育经历
2002.03-2005.12 中国科学院海洋研究所海洋生物学专业学习，获理学博士学位
1999.09-2002.02 齐鲁工业大学发酵工程专业学习，获工学硕士学位
1994.09-1998.06 齐鲁工业大学食品工程专业学习，获工学学士学位
工作经历
2018.4-至今 河北大学生命科学学院 教授，博士生导师
2006.6-2018.3 中国科学院海洋研究所实验海洋生物学重点实验室 副研究员,硕士生导师
讲授主要课程
1. 基因组学（本科生）
2. 水产动物遗传育种学（研究生）
3. 生物工业下游技术（研究生）
4. 生物医药技术与研究进展（研究生）
5. 生命科学前沿研究（研究生）
主持科研项目（2018年至今）
1. 国家自然科学基金面上项目：脊尾白虾MSTN基因缺失致死的分子机制及其基因编辑育种的理论基础，2024-2027；50万元
2. 国家自然科学基金面上项目：脊尾白虾内生蛋白SRα介导的基因编辑技术及其普适性研究，2022-2025；58万元
3. 国家自然科学基金面上项目：基于CRISPR/Cas9技术研究脊尾白虾类胡萝卜素氧化酶基因的功能及其育种价值评估；2019-2022；62万元
4. 国家重点研发计划“蓝色粮仓科技创新”项目子课题：水产养殖生物性别和发育的分子基础与调控机制；2018-2022；72.82万元
5. 河北省重点研发项目：经济甲壳动物基因编辑技术体系的建立及其在脊尾白虾分子设计育种中的应用；2022-2025；30万元
6. 河北省自然科学基金面上项目：中华锯齿米虾基因编辑平台的建立及其在分子设计育种中的应用；2019-2021；10万元
7. 河北省自然科学基金面上项目：基于因编辑技术探究dmrt基因对甲壳动物的性别调控；2023-2025；6万元
8. 河北省教育厅重点项目：甲壳动物蜕皮级联信号通路的解析；2022-2024；7.5万元
9. 河北大学多学科交叉项目：中华锯齿米虾基因组解析及分子设计育种平台建立；2019-2021；20万元
10. 横向课题：基于CRISPR/Cas9的虾蟹类基因编辑方法研究；2021-2022；2万元
论文发表（2018年至今）
1. Meng T, Ren Y, Wang Q, Lu L, Luo Y, Zhang J, Zhang Q, Dzantiev B, Negahdary M, Wan Y, Sun Y*, Song F* (2024) CRISPR-Cas14a with competitive isothermal amplification for rapid visual pathogen diagnosis. Sensors and Actuators B-Chemical 400: 134946
2. Xu C, Wang Y, Zhang R,Zhang J*, Sun Y* (2023) Molecular characterization and functional analysis of peroxiredoxin 3 (NdPrx3) fromNeocaridina denticulata sinensis. Fish & Shellfish Immunology Reports 4: 100081.
3. Yan C, Xing K, Liu Y, Kong W, Zhang R, Sun Y*,Zhang J* (2023) Genome-wide identification and expression profiling of Wnt gene family inNeocaridina denticulata sinensis. Gene 854: 147122.
4. Chen X, Yang H, Ruan Y, Zhou M, Liu J, Li Z, Wu X, Ren C, Zhang X,Zhang J, Hu C, Li H, Li G, Zhu C*, Chen T* (2023) Pacific white shrimp (Litopenaeus vannamei) vitelline membrane outer layer protein 1 (VMO1) is produced in the hepatopancreas and transported into ovarian oocytes during vitellogenesis. Gene 851: 147027.
5. Feng D, Gao X, Kong W, Wu Z, Yan C, Liu Y, Xing K, Sun Y,* Zhang J* (2022) An extracellular Cu/Zn superoxide dismutase fromNeocaridina denticulata sinensis: cDNA cloning, mRNA expression and characterizations of recombinant protein. Fish & Shellfish Immunology 128: 547-556.
6. Kong W, Wu Z, Liu Y, Yan C,Zhang J*, Sun Y* (2022) RNA-seq analysis revealing the immune response ofNeocaridina denticulata sinensis gill toVibrio parahaemolyticus infection. Fish & Shellfish Immunology 130: 409-417.
7. Liang M, Ma L, Li X, Feng D,Zhang J*, Sun Y* (2022) Identification and characterization of two types of triacylglycerol lipase genes fromNeocaridina denticulata sinensis. Fish & Shellfish Immunology 131: 980-990.
8. Liu M, Wu Z, Yan C, Liu Y, Xing K,Zhang J*, Sun Y* (2022) Ovarian transcriptome and metabolic responses of RNAi-mediated farnesyl pyrophosphate synthase knockdown inNeocaridina denticulata sinensis. Genomics 114(6): 110484.
9. Liu M, Yan C, Liu Y, Wu Z,Zhang J*, Sun Y* (2022) Cloning, expression analysis and RNAi of farnesoic acid O-methylransferase gene fromNeocaridina denticulata sinensis. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology 259: 110719.
10. Liu Y, Wu Z, Guo K, Zhou Y, Xing K, Zheng J, Sun Y*,Zhang J* (2022) Metallothionein-1 gene fromExopalaemon carinicauda and its response to heavy metal ions challenge. Marine Pollution Bulletin 175: 113324.
11. Liu Y, Xing K, Yan C, Zhou Y, Xu X, Sun Y*,Zhang J* (2022) Transcriptome analysis ofNeocaridina denticulate sinensis challenged byVibrio parahemolyticus. Fish & Shellfish Immunology 121: 31-38.
12. Liu Y, Xing K, Wu Z, Yan C, Sun Y*,Zhang J* (2022) Construction of a cytidine base editor based on cytidine deaminase and its application in crustacean genome editing. Aquaculture Reports 27: 101366
13. Wang Y, Zhang R, Xu C, Sun Y*,Zhang J* (2022) Characterization and functional analysis of peroxiredoxin 4 gene in theNeocaridina denticulata sinensis. Fish & Shellfish Immunology 122: 162-169.
14. Xing K, Liu Y, Yan C, Zhou Y, Zhang R, Sun Y*,Zhang J* (2022) Transcriptomic analysis ofNeocaridina denticulate sinensis hepatopancreas indicates immune changes after copper exposure. Fish & Shellfish Immunology 121: 23-30.
15. Yang H, Chen X, Li Z, Wu X, Zhou M, Zhang X, Liu Y, Sun Y, Zhu C, Guo Q, Chen T*,Zhang J* (2022) Genome-wide analysis indicates a complete prostaglandin pathway from synthesis to inactivation in Pacific white shrimp,Litopenaeus vannamei. International Journal of Molecular Sciences 23(3). 23031654.
16. Zhang R, Wang Y, Xu C, Chen F, Yu Q, Sun Y*,Zhang J* (2022) Characterization of peroxiredoxin fromNeocaridina denticulata sinensis and its antioxidant and DNA protection activity analysis. Fish & Shellfish Immunology 127: 211-218.
17. Zhou Y, Song Q, Liu Y, Sun Y*,Zhang J* (2022) A novel type I Crustin fromExopalaemon carinicauda: Antimicrobial ability related to conserved cysteine. Fish & Shellfish Immunology 127: 948-955.
18. Wu Z, Liu Y, Zheng J, Zhou Y, Xing K, Sun Y*,Zhang J* (2021) Genomic structure, expression and functional characterization of arginine kinase (EcAK) fromExopalaemon carinicauda. Fish & Shellfish Immunology 109: 82-86.
19. Xing K, Liu Y, Yan C, Zhou Y, Sun Y, Su N, Yang F, Xie S*,Zhang J* (2021) Transcriptome analysis ofNeocaridina denticulate sinensis under copper exposure. Gene 764: 145098.
20. Zhang X, Yang H, Li H, Chen T, Ruan Y, Ren C, Luo P, Wang Y, Liu B, Li H, Zhong P,Zhang J, Jiang X, Hu C* (2021) Molecular Identification of Anion Exchange Protein 3 in Pacific White Shrimp (Litopenaeus vannamei): mRNA Profiles for Tissues, Ontogeny, Molting, and Ovarian Development and Its Potential Role in Stress-Induced Gill Damage. Frontiers in Physiology 12: 726600.
21. Sun Y, Liu M, Yan C, Yang H, Wu Z, Liu Y, Su N, Hou J, Zhang J, Yang F,Zhang J* (2020) CRISPR/Cas9-mediated deletion of beta, beta-carotene 9', 10'-oxygenase gene (EcBCO2) fromExopalaemon carinicauda. International Journal of Biological Macromolecules 151: 168-177.
22. Sun Y, Yan C, Liu M, Liu Y, Wang W, Cheng W, Yang F,Zhang J* (2020) CRISPR/Cas9-mediated deletion of one carotenoid isomerooxygenase gene (EcNinaB-X1) fromExopalaemon carinicauda. Fish & Shellfish Immunology 97: 421-431.
23. Zhang J, Liu Y, Zhou Y, Wang W, Su N, Sun Y* (2019) Cloning of a trehalose-6-phosphate synthase gene fromExopalaemon carinicauda and its expression response to bacteria challenge. Fish & Shellfish Immunology 93: 387-394.
24. Zhang X#, Yuan J#, Sun Y#, Li S#, Gao Y#, Yu Y#, Liu C, Wang Q, Lv X, Zhang X, Ma KY, Wang X, Lin W, Wang L, Zhu X, Zhang C,Zhang J, Jin S, Yu K, Kong J, Xu P, Chen J, Zhang H, Sorgeloos P, Sagi A, Alcivar-Warren A, Liu Z, Wang L, Ruan J, Chu KH*, Liu B*, Li F*, Xiang J* (2019) Penaeid shrimp genome provides insights into benthic adaptation and frequent molting. Nature Communications 10(1): 356.
25. Zhang J, Song F, Sun Y*, Yu K, Xiang J (2018) CRISPR/Cas9-mediated deletion of EcMIH shortens metamorphosis time from mysis larva to postlarva ofExopalaemon carinicauda. Fish & Shellfish Immunology 77: 244-251.
26. Sun Y,Zhang J*, Song F, Wang J, Zhang Z, Xiang J (2018) Enzymatic characterization and functional analysis of EcChi3C from ridgetail white prawnExopalaemon carinicauda. International Journal of Biological Macromolecules 109: 448-456.
27. Sun Y,Zhang J*, Xiang J (2018) Immune function against bacteria of chitin deacetylase 1 (EcCDA1) fromExopalaemon carinicauda. Fish & Shellfish Immunology 75: 115-123.
28. Sun Y,Zhang J*, Xiang J (2018) Molecular characterization and function of beta-N-acetylglucosaminidase from ridgetail white prawnExopalaemon carinicauda. Gene 648: 12-20.
29. Zhang J, Liu Y, Li Y, Su N, Zhou Y, Xiang J, Sun Y* (2018) Biological function of a gC1qR homolog (EcgC1qR) ofExopalaemon carinicauda in defending bacteria challenge. Fish & Shellfish Immunology 82: 378-385.
30. Chen T, Lin T, Li H, Lu T, Li J, Huang W, Sun H, Jiang X,Zhang J, Yan A, Hu C, Luo P, Ren C* (2018) Heat shock protein 40 (HSP40) in Pacific white shrimp (Litopenaeus vannamei): Molecular cloning, tissue distribution and ontogeny, response to temperature, acidity/alkalinity and salinity stresses, and potential role in ovarian development. Frontiers in Physiology 9: 1784.
授权国家发明专利
1. 中国明对虾抗脂多糖因子LBD结构域突变体文库及其构建方法和应用.发明人：张继泉,宋凤阁,相建海.专利号: ZL201610506180.X
2. 一种脊尾白虾卵黄蛋白结合蛋白基因及其应用.发明人：张继泉,邢珂凡,刘玉洁,孙玉英.专利号: ZL201911421599.5
3. 基于脊尾白虾胞苷脱氨酶的单碱基基因编辑系统及其构建和应用。发明人：张继泉,刘玉洁,邢珂凡,孙玉英.专利号: ZL201911421397.0
科研教学奖励
1. 2019年河北省自然科学三等奖（第1位）
2. 2018年海洋科学技术（研究类）二等奖（第6位）
3. 杭州钱江特聘专家-虾蟹类育种高级顾问（杭州市人力资源和社会保障局，2019年-）
4. 2021年全国大学生生命科学竞赛国家级二等奖/河北省一等奖1项（指导教师）
