个人简介：
教育经历：（自大学起，时间为倒叙）
2002/9 - 2005/6，中科院海洋所，海洋生物学，博士
1999/9 - 2002/6，河北大学，水生生物学，硕士
1995/9 - 1999/6，河北大学，生物学，学士
工作经历：
2011/12 - 至今，河北大学生命科学学院，教授
2006/12 - 2011/11，河北大学生命科学学院，副教授
2002/07 - 2006/11，河北大学生命科学学院，助教
执教课程：课程名称（本科生/研究生）
“分子生物学”（本科生）、“分子免疫学原理与技术”（硕士生）、“生命科学前沿”（博士生）
科研领域：
1. 分子免疫学研究：以家蝇和沼虾等为实验材料，研究动物先天免疫应答过程，包括免疫识别、免疫信号的调理和转导、转录激活及效应分子合成等。
2. 环境毒理学研究：以大型溞和家蝇等为模式动物，研究机体对环境胁迫和典型污染物响应的分子机制，重点关注线粒体在生物适应中的作用。
代表性论文：
1．Yuan FY, Li WY, Zhang YM, Gao BX, Li FC, Tang T*, Liu FS*. Characterizing cuproptosis-like cell death in Tetrahymena thermophila: Metabolic dysfunction, oxidative stress, and mitochondrial fragmentation. Water Biology and Security. 2026. Doi: 10.1016/j.watbs.2025.100535.
2．Yuan FY, Li WY, Li AY, Tang T, Zhang YM, Xie S, Li FC*, Liu FS*. Mitochondrial remodeling and metabolic reprogramming drive long-term salinity adaptation in Tetrahymena thermophila. mSystems. 2026. Doi: 10.1128/msystems.01549-25.
3．Tang T, Fu S, Wang SY, Li KH, Wang YX, Zhou YK, Wu LL*, Liu FS*. Evolutionary diversification and metal-specific roles of metallothioneins in Musca domestica: Insights from genomic and functional analyses, International Journal of Biological Macromolecules. 2025, 331: 148377. Doi:10.1016/j.ijbiomac.2025.148377.
4．Qiu YP, Hu JY, Feng Y, Ma Y, Li C, Liu YZ, Lai YH, Wu CC, Sun RL, Tang T, Li LS*, Liu FS*. Toxicity evaluation of fosthiazate to Bombyx mori Linnaeus (Lepidoptera: Bombycidae): A new perspective from the chirality. Pesticide Biochemistry and Physiology. 2026, 216 (1): 106750. Doi: 10.1016/j.pestbp.2025.106750.
5．Zhao CC, Gu JH, Zhang YM, Zhang J, Zhao JQ, Liu FS*. Remediation of cadmium-contaminated soil with iron-modified montmorillonite: Insight for cadmium bioavailability and rhizosphere soil bacterial community. Alexandria Engineering Journal. 2025, 130: 483-493. Doi: 10.1016/j.aej.2025.09.024.
6．Tang T, Yang L, Ma LY, Ren Y, Li MN, Guo SF, Wang X, Zhang YM, Liu FS*. Resource reallocation under persistent immune activation drives trade-offs between life history and immunity in pirk-deficient Musca domestica. BMC Biology. 2025, 23 (1): 220. Doi: 10.1186/s12915-025-02324-6
7．Zhang JM, Tang T, Lin DD, Ma LY, Liu FS*. Identification of hemocyte types and characterization of their immune function in the house fly based on morphological observation and single-cell RNA sequencing. Insect Biochemistry and Molecular Biology. 2025, 182: 104358. doi: 10.1016/j.ibmb.2025.104358.
8．Zhang YM, Tian XL, Li HT, Zhang YJ, Zhang YW, Chen MX, Ni ZH, Gu JH, Tang T, Xie S, Liu FS*. Mechanisms underlying the chronic toxicity of ofloxacin to Daphnia magna: Oxidative stress, mitochondrial dysfunction, and energy allocation. Environmental Pollution. 2025, 382:126764. doi: 10.1016/j.envpol.2025.126764.
9．Lin DD, Li SS, Li SY, Tang T*, Liu FS*. Identification and functional characterisation of a novel antimicrobial peptide from the housefly, Musca domestica. Insect Mol Biol. 2025, 34:807–816. doi: 10.1111/imb.13005.
10．Zheng Yuanjing, Li Yue, Wei Zhengyang, Wang Yang, Liu Yuanlin, Liu Fengsong, Li Xue, Zhang Yi. HUC-MSC-derived exosomal miR-16-5p attenuates inflammation via dual suppression of M1 macrophage polarization and Th1 differentiation. Biochemistry and Biophysics Reports. 2025, 43: 102078. Doi: 10.1016/j.bbrep.2025.102078.
11．Li MY, Qin N, Yuan BW, Guo MH, Yang LK, Tang T, Li FC*, Liu FS*. Involvement of nerve cord-expressed SVWC2 in pathogen recognition and defense in Macrobrachium nipponense, Fish & Shellfish Immunology. 2025, 162: 110329. Doi: 10.1016/j.fsi.2025.110329.
12．Li AY, Yuan FY, Li LS, Gu JH, Zhang YM, Li FC, Tang T, Liu FS*. Interactions between nanoplastics and Tetrahymena thermophila: Low toxicity vs. potential biodegradation. Chemosphere. 2025, 373: 144166. Doi: 10.1016/j.chemosphere.
13．Zhang YM, Lv JH, Sun XL, Zhang YW, Shao MH, Shi BB, Zhang YJ, Gu JH, Zhao CC, Liu FS*. Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity. Ecotoxicology and Environmental Safety, 2025, 289: 117656, doi: 10.1016/j.ecoenv.2024.117656.
14．Ni ZH, Tian XL, Zhao WB, Hu WK, Lv JH, Sun XL, Zhang YJ, Zhang YW, Zhang YM, Li BK*, Liu FS*. The detrimental effects and mechanisms of orlistat in disrupting energy homeostasis and reproduction in Daphnia magna. Aquatic Toxicology, 2025, 279: 107201. doi: 10.1016/j.aquatox.2024.107201.
15．Tang T, Sun SY, Wang RR, Li MN, Wang YP, Li FF, Wang Y, Liu FS*. MdSVWC1, a new pattern recognition receptor triggers multiple defense mechanisms against invading bacteria in Musca domestica. BMC Biology, 2024, 22: 242. doi: 10.1186/s12915-024-02042-5.
16．Tang T, Wu MJ, Yang LK, Liu FS*, Zhang F*. Muscle LIM protein of Macrobrachium nipponense (MnMLP) involved in immune and stress response. Fish Shellfish Immunol, 2024, 153: 109809. doi: 10.1016/j.fsi.2024.109809.
17．Zhang YM, Xiu WJ, Yan M, Guo XR, Ni ZH, Gu JH, Tang T, Liu FS*. Adverse effects of sulfamethoxazole on locomotor behavior and lipid metabolism by inhibiting acetylcholinesterase and lipase in Daphnia magna. Science of the Total Environment, 2023, 892: 164631. doi: 10.1016/j.scitotenv.2023.164631
18．Qin N, Li MY, Zhang H, Li FF, Guo XR, Wu MJ, Zhang QL, Tang T*, Liu FS*. Single von Willebrand factor C-domain protein confers host defense against white spot syndrome virus by functioning as a pattern recognition receptor in Macrobrachium nipponense. Int J Biol Macromol, 2023, 241: 124520. doi: 10.1016/j.ijbiomac.2023.124520
19．Liang YD, Yang L, Wang YP, Tang T, Liu FS*, Zhang F*. Peptidoglycan recognition protein SC (PGRP-SC) shapes gut microbiota richness, diversity and composition by modulating immunity in the house fly Musca domestica. Insect Molecular Biology, 2023, 32(2): 200-212. doi: 10.1111/imb.12824
20．Li MY, Tang T, Yuan FY, Zhang YM, Li FC, Liu FS*. Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure. Science of the Total Environment, 2022, 484: 157565. doi: 10.1016/j.scitotenv.2022.157565
21．Zhang YM, Yuan FY, Li P, Gu JH, Han JJ, Ni ZH*, Liu FS*. Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function. Ecotoxicology and Environmental Safety, 2022, 241: 113788. doi: 10.1016/j.ecoenv.2022.113788
22．Gu JH, Lin DD, Sun YY, Guo YZ, Chen B, Zhang YM, Liu FS*. Integrating transcriptome and physiological analysis to reveal the essential responses of Daphnia magna to antimony trioxide nanoparticle. Journal of Hazardous Materials, 2022, 437: 129303. doi: 10.1016/j.jhazmat.2022.129303
23．Li J, Li HT, Lin DD, Li MY, Wang QS, Xie S, Zhang YM*, Liu FS*. Effects of Butyl benzyl phthalate exposure on Daphnia magna growth, reproduction, embryonic development and transcriptomic responses. Journal of Hazardous Materials, 2021, 404: 124030. doi: 10.1016/j.jhazmat.2020.124030
24．Qin N, Sun HH, Lu MK, Wang JH, Tang T*, Liu FS*. A single von Willebrand factor C-domain protein acts as an extracellular pattern-recognition receptor in the river prawn Macrobrachium nipponense. Journal of Biological Chemistry, 2020, 295(30): 10468-10477. doi:10.1074/jbc.RA120.013270
25．Cao XR, Li YB, Li SS, Tang T*, Liu FS*. Two ferritin genes (MdFerH and MdFerL) are involved in iron homeostasis, antioxidation and immune defense in housefly Musca domestica. Journal of Insect Physiology, 2020, 124: 104073. doi: 10.1016/j.jinsphys.2020.104073
26．Feng Q, Shao MH, Han JJ, Tang T, Zhang YM*, Liu FS*. TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol, 2020, 155: 524-534. doi: 10.1016/j.ijbiomac.2020.03.208.
27．Qin N, Wu MJ, Tang T*, Liu FS*. A fibrinogen-related protein (Mnfico3) acts as a novel pattern recognition receptor in Macrobrachium nipponense. Fish & Shellfish Immunology, 2020, 100: 272-282. doi: 10.1016/j.fsi.2020.02.066.
28．Zhang YM, Li YJ, Feng Q, Shao MH, Yuan FY, Liu FS*. Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere, 2020, 248: 126009. doi: 10.1016/j.chemosphere.2020.126009.
29．Tang T, Liu JL, Li SS, Li HQ, Liu FS*. Recombinant expression of an oriental river prawn anti-lipopolysaccharide factor gene in Pichia pastoris and its characteristic analysis. Fish & Shellfish Immunology, 2020, 98: 414-419. doi: 10.1016/j.fsi.2020.01.030.
30．Wang XF, Gao S, Hao ZX, Tang T*, Liu FS*. Involvement of TRAF6 in regulating immune defense and ovarian development in Musca domestica. Int J Biol Macromol, 2020, 153: 1262-1271. doi: 10.1016/j.ijbiomac.2019.10.259.
31．Yuan FY, Yang ZL, Tang T, Xie S*, Liu FS*. A 28.6-kD small heat shock protein (MnHSP28.6) protects Macrobrachium nipponense against heavy metal toxicity and oxidative stress by virtue of its anti-aggregation activity. Fish & Shellfish Immunology, 2019, 95: 635-643. doi: 10.1016/j.fsi.2019.10.053.
32．Sun JS, Shi JH, Wang YH, Wu SJ, Zhao LP, Li YC, Wang H, Chang L, Lyu ZT, Wu JZ, Liu FS*, Li WJ*, He FC*, Zhang Y*, Xu P*. Open-pFind enhances the identification of missing proteins from human testis tissue. J. Proteome Res. 2019, 18: 4189-4196. doi: 10.1021/acs.jproteome.9b00376.
33．Qin N, Tang T, Liu X, Xie S*, Liu FS*. Involvement of a TNF homologue in balancing the host immune system of Macrobrachium nipponense. Int J Biol Macromol, 2019, 134: 73-79. doi: 10.1016/j.ijbiomac.2019.05.045.
34．Tang T, Yang ZL, Li J, Yuan FY, Xie S*, Liu FS*. Identification of multiple ferritin genes in Macrobrachium nipponense and their involvement in redox homeostasis and innate immunity. Fish & Shellfish Immunology, 2019, 89: 701-709. doi: 10.1016/j.fsi.2019.04.050.
35．Tang T, Sun HH, Li YB, Chen PR, Liu FS*. MdRDH1, a HSP67B2-like rhodanese homologue plays a positive role in maintaining redox balance in Musca domestica. Molecular Immunology, 2019, 107:115-122. doi: 10.1016/j.molimm.2019.01.016.
36．Zhang YM, Wang F, Feng Q, Wang HX, Tang T, Huang DW, Liu FS*. Involvement of trehalose-6-phosphate synthase in innate immunity of Musca domestica. Developmental & Comparative Immunology, 2019, 91: 85-92. doi: 10.1016/j.dci.2018.10.010.
37．Tang T, Li WQ, Wang XF, Wu YJ, Liu FS*. A house fly TNF ortholog Eiger regulates immune defense via cooperating with Toll and Imd pathways. Developmental & Comparative Immunology, 2019, 90: 21-28. doi: 10.1016/j.dci.2018.08.016.
38．Tang T, Li X, Liu X, Wang YL, Ji CC, Wang Y, Wang XC, Xie S, Liu FS*, Wang JH*. A single-domain rhodanese homologue MnRDH1 helps to maintain redox balance in Macrobrachium nipponense. Developmental & Comparative Immunology, 2018, 78: 160-168. doi: 10.1016/j.dci.2017.09.022.
39．Tang T, Ji CC, Yang ZL, Liu FS*, Xie S*. Involvement of the Macrobrachium nipponense rhodanese homologue 2, MnRDH2 in innate immunity and antioxidant defense. Fish & Shellfish Immunology, 2017, 70: 327-334. doi: 10.1016/j.fsi.2017.09.010.
40．Ma XY, Wang JH, Ma CX, Wang JL, Wang XC, Liu FS*. Malat1 as an evolutionarily conserved lncRNA, plays a positive role in regulating proliferation and maintaining undifferentiated status of early-stage hematopoietic cells. BMC Genomics, 2015, 16(1):676. doi: 10.1186/s12864-015-1881-x.
41．Gao YF, Tang T, Gu JH, Sun LL, Gao XB, Ma XY, Wang XC, Liu FS*, Wang JH*. Down regulation of the Musca domestica peptidoglycan recognition protein SC (PGRP-SC) leads to over expression of antimicrobial peptides and tardy pupation. Molecular Immunology, 2015, 67(2 Pt B): 465-474. doi:10.1016/j.molimm.2015.08.007.
42．Wang YL, Tang T, Gu JH, Li X, Yang X, Gao XB, Liu FS*, Wang JH*. Identification of five anti-lipopolysaccharide factors in oriental river prawn, Macrobrachium nipponense. Fish & Shellfish Immunology, 2015, 46(2):252-260. doi: 10.1016/j.fsi.2015.07.003.
43．Chen HJ, Yang X, Tang T, Li J, Liu BZ, Liu FS*, Xie S*. The involvement of cysteine-rich intestinal protein in early development and innate immunity of Asiatic hard clam, Meretrix meretrix. Fish & Shellfish Immunology, 2014, 40(2): 435-440. doi: 10.1016/j.fsi.2014.07.027.
44．Tang T, Li X, Yang X, Yu X, Wang JH, Liu FS*, Huang DW*. Transcriptional response of Musca domestica larvae to bacterial infection. PLoS One. 2014, 9(8): e104867. doi: 10.1371/journal.pone.0104867.
45．Tang T, Li LX, Sun LL, Bu JC, Xie S, Liu FS*. Functional analysis of Fenneropenaeus chinensis anti-lipopolysaccharide factor promoter regulated by lipopolysaccharide and (1, 3)--D-glucan. Fish & Shellfish Immunology, 2014, 38 (2): 348-353. doi:10.1016/j.fsi.2014.03.026.
46．Tang T, Wu C, Li JG, Ren GD, Huang DW*, Liu FS*. Stress-induced HSP70 from Musca domestica plays a functionally significant role in the immune system. Journal of Insect Physiology, 2012, 58: 1226-1234. doi: 10.1016/j.jinsphys.2012.06.007.
47．Tang T, Huang DW*, Zhou CQ, Li X, Xie QJ, Liu FS*. Molecular cloning and expression patterns of copper/zinc superoxide dismutase and manganese superoxide dismutase in Musca domestica. Gene, 2012, 505: 211-220.doi: 10.1016/j.gene.2012.06.025.
48．Liu FS*, Tang T, Sun LL, Priya TA. Transcriptomic analysis of the housefly (Musca domestica) larva using massively parallel pyrosequencing. Molecular Biology Reports, 2012, 39(2): 1927-1934. DOI: 10.1007/s11033-011-0939-3.
49．Dong XY, Liu FS*, Zhang D, Tang T, Ge XD. Identification and characterization of cysteine protease inhibitor gene MdCPI from Musca domestica. Insect Molecular Biology, 2011, 20(5), 577-586. doi:10.1111/j.1365-2583.2011.01088.x.
50．Tang T, Huang DW, Zhang D, Wu YJ, Murphy RW, Liu FS*. Identification of two metallothionein genes and their roles in stress responses of Musca domestica toward hyperthermy and cadmium tolerance. Comparative Biochemistry and Physiology, Part B, 2011, 160 (2-3): 81-88. doi:10.1016/j.cbpb.2011.06.008.
51．Liu FS, Li FH, Dong B, Wang XM, Xiang JH. Molecular cloning and characterisation of a pattern recognition protein, lipopolysaccharide and beta-1, 3-glucan binding protein (LGBP) from Chinese shrimp Fenneropenaeus chinensis. Molecular Biology Reports, 2009, 36(3): 471-477.
52．Xie S, Sun LN, Liu FS*, Dong B. Molecular characterization and mRNA transcript profile of vitellogenin in Chinese shrimp, Fenneropenaeus chinensis. Molecular Biology Reports, 2009,36(2):389-397.
53．Liu FS, Li FH, Xiang JH, Dong Bo, Liu YC, Zhang XJ, Zhang LS. Molecular cloning and expression analysis of crustin-like gene from Chinese shrimp Fenneropenaeus chinensis. Acta Oceanologica Sinica, 2008, 27(2): 81-92.
54．Liu FS, Liu YC, Li FH, Dong B, Xiang JH. Molecular cloning and expression profile of putative anti-lipopolysaccharide factor (ALF) in Chinese shrimp Fenneropenaeus chinensis. Marine Biotechnology, 2005, 7(6):600-608.
