康乐

职称:研究员/院士,博士生导师

邮箱:lkang@hbu.edu.cn

地址:河北省保定市五四东路180号,河北大学生命科学学院

邮政编码:071002

  • 个人简介

 

 

康乐,1959年生,博士生导师,中国科学院院士、EMBO外籍成员(院士)、欧洲科学院院士、美国科学院外籍院士、发展中国家科学院院士、国际欧亚科学院院士、非洲科学院院士、中国科学院动物研究所杰出研究员、我国著名生态学家和昆虫学家。

长期从事生态基因组学研究,通过将分子生物学与生态学结合,系统研究动物适应性和表型可塑性。主持国家“973”项目、国家基金委创新群体和中国科学院先导专项等重大研究项目多项。重要研究成果发表在Nature, Science, Science Advances,Nature Communications, PNAS, Genome Biology,MBE,eLife, PLoS Genetics等国际著名刊物。发表SCI论文260余篇,被国际SCI期刊引用6300余次,是Elsevier中国高被引学者(2014-2023,Scopus)。

已培养河北大学博士毕业生3名、硕士毕业生5名;在读博士研究生11名,硕士研究生19名。

担任国际昆虫学会执行理事,中国昆虫学会名誉理事长,国际生命科学联合会(IUBS)中国委员会主席、国际生命科学联合会(IUBS)副主席、中国科协全委会、国家基金委全委会委员。1998年被评为国家有突出贡献的专家,获得国务院特殊津贴。1999年获国家自然科学三等奖,2011年获何梁何利生命科学与技术进步奖,2013年获美国昆虫学会国际杰出科学家奖,2015年获谈家桢生命科学奖成就奖,2016年获全国优秀科技工作者荣誉称号,2017年获国家自然科学奖二等奖,中国科学院杰出科技成就奖,2018年获河北省“巨人计划”第三批创新创业团队领军人才称号,2019年获河北省科技创新团队,马世骏生态科学成就奖和河北省教学成果奖一等奖,2021年获国际化学生态学会西弗斯坦-西蒙尼奖,2023年获第三届全国创新争先奖状表彰。

硕士研究生招生专业071010生物化学与分子生物学

博士研究生招生专业:071000生物学

实验室研究方向

生态基因组研究方向:动物对环境的适应性是生命科学领域的重要研究方向。该研究方向利用分子生物学、基因组学和结构生物学为研究手段,在基因组、转录组、翻译组以及表观遗传水平系统研究动物对环境的适应性。以昆虫和动物为模式系统,研究动物的适应性和表型可塑性的分子调控机制以及昆虫行为的基因调控,为解析动物行为的机制、智能化基础和发展人类疾病模型提供依据。

主持科研项目

1. 2016-,白洋淀流域生态保护与京津冀可持续发展协同中心,200万元/年

2. 2021.01-2025.12,生物信息流的解码与操纵,国家基金委基础科学中心项目,1200万元。

3. 2020.01-2024.12,作为昆虫嗅觉进化重要节点的飞蝗嗅觉编码与处理机理研究,国家自然科学基金国际合作重点项目,265万元;

4. 2020.01-2023.12,京津冀环境健康与管理国际联合研究,河北省外专百人计划项目,150万元;

5. 2019.01-2022.12,飞蝗嗅觉吸引行为的神经分子机制,国家自然科学基金面上项目31872303,61万元;

6. 2019.09-2021.08,河北省环境健康与治理国际联合研究中心,河北省科技厅19393610D,30万元;

7. 2018.04-2021.04,河北省“巨人计划”第三批创新创业团队,河北大学基因表达与DNA修复创新团队项目,200万元;

8. 2017.09-2019.09,雄安新区土地利用变化、生态环境和水资源对产业布局的影响,中国科学院学部工作局(A类),200万元;

9. 2015.01-2019.12,多巴胺代谢相关长非编码RNA调控飞蝗型变可塑性的机理研究,国家自然科学基金重点项目31430023,317万元;

10. 2014.07-2019.06,作物病虫害的导向性防控-生物间信息流与行为操纵,中国科学院战略性先导科技专项(B类)资助,XDB11010000,5913万元;

代表论著

1. Li, J.,Wei*, L.Y., Wang, Y.S., Zhang,HK., Yang, P.C., Zhao, Z.W., andKang*, L. 2023. Cytosolic and mitochondrial ribosomal proteins mediate the locust phase transition via divergence of translational profiles.PNAS, 120(5), e2216851120. [PDF]

2. Yang, M.L., Du, B.Z., Xu, L.L., Wang, H.M., Wang, Y.L., Lin, K., He, G.F.,Kang*,L. 2023. Glutamate-GABA imbalance mediated by miR-8-5p and its STTM regulates phase-related behavior of locusts.PNAS. 120(1), e2215660120.[PDF]

3. Huang, X.L.,1,7 Li, Q.,2,3,7 Xu,Y.A.,4,7 Li, A.,5,7 Wang, S.Z.,5 Chen, Y.S.,5 Zhang, C.R.,3 Zhang, X.,3 Wang, H.L.,6 Lv, C.,6 Sun, B.F.,5 Li S.Q.,2 Kang, L. 1,3*, Chen, B.1*. A neural m6A pathway regulates behavioral aggregation in migratory locusts. Science China-Life Science,doi:10.1007/s11427-023-2476-1.[PDF]

4. Chen#*, B., Tong#, X.W., Zhang, X., Gui, WY., Ai, G.M., Huang, L.H., Ding, D., Zhang, J.X.,Kang*, L. 2022. Sulfation modification of dopamine in brain regulates aggregative behavior of animals.National Science Review, doi:10.1093/nsr/nwab163.[PDF]

5. Wang, Y., Lou, H.F., Wang, C.S., Ni, M., Yu, D., Zhang, L.,Kang*, L. 2022. Hexamerin-2 Protein as a Novel Allergen in Occupational Locust Allergy.Journal of asthma and allergy, 15: 145-155.[PDF]

6. Wang,X.X., Fan,J.L.,Zhou,M.,Gao,G. Wei*,L.Y.,Kang*, L. 2021.Interactive effect of photoperiodand temperature on the induction and termination of embryonic diapause in the migratory locust.Pest Management Science, 77(6) 2854-2862.[PDF]

7. Wang,X.X., Li,J., Wang, T.X., Yang, Y.N., Zhang, H.K., Zhou, M.,Kang*, L.,Wei*, L.Y. 2021.A novel non-invasive identification of genome editing mutants from insect exuviae,Insect Science.doi: 10.1111/1744-7917.12914.[PDF]

8. Guo, X.J., Yu, Q.Q., Chen, D.F., Wei, J.N., Yang, P.C., Yu, J., Wang*, X.H., and Kang*, L.2020. 4-Vinylanisole is an aggregation pheromone in locusts.Nature, https:// doi.org/10.1038/s41586-020-2610-4.[PDF]

9. Tong, X.W., Wang, Y.D., Yang P.C., Wang, C.S., and Kang*, L. 2020. Tryptamine accumulation caused by deletion of MrMao-1 in Metarhizum genome significantly enhances insecticidal virulence.PLoS Genetics, 16(4): e1008675.[PDF]

10. Zhang,X., Xu, Y.N., Chen, B., Kang*, L. 2020.Long noncoding RNA PAHAL modulates locust behavioral plasticity through the feedback regulation of dopamine biosynthesis. PLoS Genetics, 16(4): e1008771.[PDF]

11. Guo, W., Juan Song, J., Yang, P.C., Chen, X.Y., Chen, D.F., Ren, D.N., Kang*, L., Wang, X.H., 2020. Juvenile hormone suppresses aggregation behavior through influencing antennal gene expression in locusts. PLoS Genetics, 16(4): e1008762.[PDF]

12. Su, Y., Wei, L.Y., Tan, H., Li, J., Li, W.P., Fu, L., Wang, T.X.,Kang*, L., Yao*, X.S. 2019. Optical coherence tomography as a noninvasive 3D real time imaging tool for the rapid evaluation of phenotypic variations in insect embryonic development.Journal of biophotonics,13(2): e201960047.[PDF]

13. Kang*, L.2019. Overview:biotic signaling for smart pest management.Philosophical Transactions of the Royal Society B, 374(1767): 20180306.[PDF]

14. Yang, M.L., Wang, Y.L., Liu, Q., Liu, Z.K., Jiang, F., Wang, H.M., Guo, X.J., Zhang*, J.Z., and Kang*, L. 2018. A β-carotene-binding protein carrying a red pigment regulates body-color transition between green and black in locusts. eLife, 7:e41362.[PDF]

15. Wei, J.N., Shao, W.B., Cao, M.M., Ge, J., Yang, P.C., Chen, L., Wang, X.H., Kang*, L. 2019. Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor.Science Advances,5(1): 1-13.[PDF].

16. Guo, X.J., Ma, Z.Y., Du, B.Z., Li, T., Li, W.D., Xu, L.L., He, J., and Kang*, L. 2018. Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts.Nature Communications, 9(1): 1193.[PDF]

17. Ding, D., Liu, G.J., Hou, L., Gui, W.Y., Chen*, B., and Kang*, L. 2018. Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts. Nature Communications. 9(1):p.4991. [PDF]

18. Hou L., Yang P.C., Jiang F., Liu Q.,Wang X.H.,Kang L. 2017. The neuropeptide F/nitric oxide pathway is essential for shaping locomotor plasticity underlying locust phase transition. eLife, DOI:10.7554/eLife.22526 [PDF]

19. Chen B., Zhang B., Xu L.L., Li Q., Jiang F., Yang P.C., Xu Y.N., Kang L. 2017. Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation. Molecular Biology and Evolution. doi:10.1093/molbev/msx062. [PDF]

20. Jiang F., Liu Q., Wang Y.L., Zhang J., Wang H.M., Song T.Q., Yang M.L., Wang X.H., Kang L. 2017. Comparative genomic analysis of SET-domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. GigaScience, DOI: 10.1093/gigascience/gix031.[PDF]

21. He, J., Chen, Q.Q., Wei, Y.Y., Jiang, F., Yang, M.L., Hao, S.G., Guo, X.J., Chen, D.F., Kang, L. 2016. MicroRNA-276 promotes egg hat ching synchrony by upregulating brm in locusts. Proceeding of the National Academy of Sciences of the USA, 113:584-589.[PDF]

22. Yang M.L., Wang Y.L., Jiang F., Song T.Q., Wang H.M., Liu Q, Zhang J., Zhang J.Z., Kang L. 2016. miR-71 and miR-263 Jointly Regulate Target Genes Chitin synthase and Chitinase to Control Locust Molting. PLoS Genetics, 12:e1006257. [PDF]

23. Wang,X.H., Kang,L. 2014.Molecular mechanisms of phase change in locusts. Annual Review of Entomology, 59:225-43. [PDF]

24. Wang, X.H., Fang, X.D., Yang, P.C., Jiang, X.T., Jiang, F.,….. Kang, L. 2014. Locust genome sequence provides insight into swarm formation and long-distance flight. Nature Communications, 10.1038/ncomms3957. [PDF]

25. Yang, M.L., Wei, Y.Y., Jiang, F., Wang, Y.L., Guo, X.J., He, J., Kang, L. 2014. MicroRNA-133 Inhibits Behavioral Aggregation by Controlling Dopamine Synthesis in Locusts. PLoS Genetics,10(2): e1004206. doi:10.1371/journal.pgen.1004206.[PDF]

26. Wang, Y.D., Yang, P.C., Cui, F., Kang, L. 2013. Altered Immunity in Crowded Locust Reduced Fungal (Metarhizium anisopliae) Pathogenesis. PLoS Pathogens, DOI:10.1371/journal.ppat.1003102. [PDF]

27. Wei, J.N, Yang, L.H, Ren, Q, Li, CY, Ge, F., Kang, L. 2013. Antagonism between plant odors and trichomes affects tritrophic interactions. Plant Cell & Environment, 36, 315-327. [PDF]

28. Cease, AJ, Elser, JJ, Ford, CF, Hao, S., Kang, L, Harrison*, JF. 2012. Heavy livestock grazing promotes locust outbreaks by lowering plant nitrogen content. Science, 335, 467-469. [PDF]

29. Wu, R., Wu, Z.M., Wang, X.H., Yang, P.C., Yu, D., Zhao, C.X., Xu, G.W., and Kang, L. 2012. Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts. Proceedings of National Academy of Sciences(USA), 109, 3259-3263. [PDF]

30. Ma, ZY, Guo, XJ, Guo, W, Wang, XH, Kang, L. 2011. Modulation of behavioral phase changes of the migratory locust by the catecholamine metabolic pathway. Proceedings of National Academy of Sciences (USA), 108: 3882-3887. [PDF]

31. Guo, W, Wang, XH, Ma, Z.Y., Xue, L., Han, J.Y., Yu, D., and Kang, L. 2011. CSP and takeout genes modulate the switch between attraction and repulsion during behavioral phase change in the migratory locust. PLoS Genetics, 7(2): e1001291, 1-13.[PDF]

32. Wei, J.N., Wang, L.Z., Zhao, J.H., Li, C.Y., Ge, F. and Kang, L. 2011. Ecological trade-offs between jasmonic acid-dependent direct and indirect plant defences in tritrophic interactions. New phytologist, 189: 557–567. [PDF]

33. Zhang, Y., Wang, X.H., and Kang, L., 2011. A k-mer scheme to predict piRNAs and characterize locust piRNAs. Bioinformatics, 27(6)771–776. [PDF]

34. Kang, L., Chen, B., Wei, J.N. and Liu, T.X., 2009. Roles of Thermal Adaptation and Chemical Ecology in Liriomyza Distribution and Control. Annual Review of Entomology, 54:127-145. [PDF]

35. Wei, Y.Y., Chen, S., Yang P.C., Kang, L., 2009. Characterization and transcriptomes of small RNAs in two phases of locust. Genome Biology, 10:R6l (doi:10.1186/gb-2009-10-1-r6). [PDF]

36. Kang, L., Han, X.G., Zhang, Z.B. and Sun, O. J., 2007, Grassland ecosystems in China: Review of current knowledge and research advancement. Philos. Trans. Roy. Soc.,362:997-1008.[PDF]

37. Kang, L., Chen, X.Y., Zhou, Y., Zheng, W., Li R.Q., Wang, J. and Yu, J. 2004. The analysis of large-scale gene expression correlated to the phase changes of the migratory locust.Proceeding of the National Academy of Sciences of the USA, 101: 17611-17615. [PDF]

38. 生态基因组学,康乐主编,2019,北京:科学出版社。

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